4-Hydroxysalicylic acid
2,4-Dihydroxybenzoic acid
CAS: 89-86-1
Molecular Formula: C7H6O4
4-Hydroxysalicylic acid - Names and Identifiers
| Name | 2,4-Dihydroxybenzoic acid |
| Synonyms | 2,4-Dihydrox -Resorcylicacid β-Resorcylic acid SS-RESORCYLIC ACID beta-Resorcylic Acid BETA RESORCYLIC ACID 2,4-dihydroxybenzoate Resorcylic acid, beta p-hydroxysalicylicacid 4-Hydroxysalicylic acid 2,4-Dihydroxybenzoesure 2,4-Dihydroxybenzoic acid Sodium aminosalicylate Impurity 3 |
| CAS | 89-86-1 |
| EINECS | 201-946-9 |
| InChI | InChI=1/C7H6O4/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,8-9H,(H,10,11)/p-1 |
| InChIKey | UIAFKZKHHVMJGS-UHFFFAOYSA-N |
4-Hydroxysalicylic acid - Physico-chemical Properties
| Molecular Formula | C7H6O4 |
| Molar Mass | 154.12 |
| Density | 1.3725 (rough estimate) |
| Melting Point | 208-211 °C (dec.) (lit.) |
| Boling Point | 237.46°C (rough estimate) |
| Flash Point | 200 °C |
| JECFA Number | 908 |
| Water Solubility | 8 g/L (20 ºC) |
| Solubility | Soluble in hot water, ethanol, ether. Boil in water, acid or salt solution will remove carbon dioxide. It is red when it reacts with ferric chloride. |
| Vapor Presure | 0Pa at 25℃ |
| Appearance | White crystal |
| Color | Cream to slightly beige or pink |
| Merck | 14,8157 |
| BRN | 1946213 |
| pKa | 3.11, 8.55, 14.0(at 25℃) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Sensitive | Sensitive to light |
| Refractive Index | 1.6710 (estimate) |
| MDL | MFCD00002451 |
| Physical and Chemical Properties | Appearance: white to light cream powder Melting Point: 158~163 ℃ |
| Use | Used as dye, medicine, pesticide intermediates |
4-Hydroxysalicylic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 1 |
| RTECS | VH3708050 |
| TSCA | Yes |
| HS Code | 29182990 |
4-Hydroxysalicylic acid - Reference
| Reference Show more | 1. Optimization of separation and purification of phenolic compounds from black barley bran by macroporous resin 2. Yang Xijuan, Fang Bin, fan Mingtao. Effects of solvent extraction on composition and antioxidant activity of different forms of polyphenols in highland barley [J]. Food Science, 2018, 39(24):246-255. 3. [IF = 4.821] Chuanying Zhang et al."Investigation on the interaction of brazilin with bovine serum atomin using multi-spectroscopical and computational methods: Exploring the binding mechanism and effect on amyloid aggregation." Microchem J. 2020 Dec;159:1055 4. [IF = 2.478] Kun Li et al."Composition, antivirence Activity, and Active Property Distribution of the Fruit of Terminalia chebula Retz."J Food Sci. 2019 Jul;84(7):1721-1729 5. [IF=4.412] Hui-Min Jin et al."Polyphenol and Anthocyanin Composition and Activity of Highland Barley with Different Colors."MOLECULES. 2022 Jan;27(11):3411 |
4-Hydroxysalicylic acid - Introduction
Iron drip analysis reagent. Dyes and pharmaceutical intermediates. The product has the chemical properties of resorcinol and salicylic acid, and is used for the colorimetric determination of iron, titanium and other elements by chemical reagents; when used in organic synthesis, it is mainly used as a dye and pharmaceutical intermediate.
Last Update：2022-10-16 17:29:39
4-Hydroxysalicylic acid - Reference Information
| FEMA | 3798 | 2,4-DIHYDROXYBENZOIC ACID |
| LogP | 0.98 at 23℃ and pH3.5 |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| toxicity | GRAS(FEMA). |
| usage limit | FEMA(mg/kg): Cold drink 450; Meat products, dairy products, processed vegetables, 100; Soft candy, gel, pudding, snack food, beverage, breakfast cereal, fat, cheese, poultry products, fish, condiment, sweet sauce, milk substitute, meat soup, fruit ice, egg products, jam, jelly, rehydrated vegetables, 500; Soup 250; Gum 3333; Instant coffee and tea 12.5; Sugar substitutes 12500; Spices 25000. |
| Use | This product has the chemical properties of resorcinol and salicylic acid, and is used for the Colorimetric Determination of iron, titanium and other elements by chemical reagents; used in organic synthesis, mainly as dyes and drug intermediates. 2,4-Dihydroxybenzoic acid is a major raw material in the production of the acid medium pink 3BM, which consumes 100% per ton of dye (as per). used as dye intermediate, medicine and reagent used as dye, medicine and pesticide intermediate drop analysis reagent of iron. Dyes and drug intermediates. It has the chemical properties of resorcinol and salicylic acid, and is used for the Colorimetric Determination of iron, titanium and other elements by chemical reagents. When used in organic synthesis, it is mainly used as dye and drug intermediate. |
| production method | is obtained by hydroxylation of resorcinol. |
Last Update：2024-04-09 15:16:53
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